Nanomedicine Reformulation of Chloroquine and Hydroxychloroquine
نویسندگان
چکیده
منابع مشابه
Chloroquine and hydroxychloroquine for cancer therapy
Macroautophagy (herein referred to as autophagy) is a highly conserved mechanism for the lysosomal degradation of cytoplasmic components. Autophagy is critical for the maintenance of intracellular homeostasis, both in baseline conditions and in the context of adaptive responses to stress. In line with this notion, defects in the autophagic machinery have been etiologically associated with vario...
متن کاملRecommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy (2016 Revision).
BACKGROUND The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. PATTERN OF RETINOPATHY Although the locus of toxic damage is parafoveal in many eyes, Asian patients often s...
متن کاملRevised recommendations on screening for chloroquine and hydroxychloroquine retinopathy.
BACKGROUND The American Academy of Ophthalmology recommendations for screening of chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy were published in 2002, but improved screening tools and new knowledge about the prevalence of toxicity have appeared in the ensuing years. No treatment exists as yet for this disorder, so it is imperative that patients and their physicians be aware of the ...
متن کاملSevere, reversible dysphagia from chloroquine and hydroxychloroquine myopathy.
An 89-year-old man presented with a 3-year history of progressive oropharyngeal dysphagia with both solids and liquids. He had no fatigability of chewing or swallowing but had difficulty propelling the bolus back to his posterior pharynx. His dysphagia was profound, and he had lost over 20 pounds of weight. He twice developed aspiration pneumonia. He was otherwise in good health and had longsta...
متن کاملChloroquine/Hydroxychloroquine AND SARS-CoV 2; lessons from case-control studies
Chloroquine has several disadvantages consisting hypoglycemia, diarrhea, prolong QTc interval, and AV block (21-22). In addition, Gendelman et al., recently published an article about inefficacy of continuous Hydroxychloroquine or colchicine therapy for prevention of SARS-CoV 2 infection (23). According to recent RCTs, HCQ has no therapeutic effects on prevention or improvment of major outcomes...
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ژورنال
عنوان ژورنال: Molecules
سال: 2020
ISSN: 1420-3049
DOI: 10.3390/molecules26010175